Accessory protein function in the DNA polymerase III holoenzyme fromE. coli
- 1 February 1992
- Vol. 14 (2), 105-111
- https://doi.org/10.1002/bies.950140206
Abstract
DNA polymerases which duplicate cellular chromosomes are multiprotein complexes. The individual functions of the many proteins required to duplicate a chromosome are not fully understood. The multiprotein complex which duplicates the Escherichia coli chromosome, DNA polymerase III holoenzyme (holoenzyme), contains a DNA polymerase subunit and nine accessory proteins. This report summarizes our current understanding of the individual functions of the accessory proteins within the holoenzyme, lending insight into why a chromosomal replicase needs such a complex structure.Keywords
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