Intraocular penetration of systemically administered antifungal agents

Abstract

Amphotericin B, 5-flucytosine (5-FC), and ketoconazole levels were estimated in vitreous and aqueous samples taken from four patients undergoing therapeutic vitrectomy for fungal endophthalmitis. The levels of amphotericin B in the vitreous of three patients were low (.04–.17 µg/ml). However, 5-FC was present in a concentration of 22.2 µg/ml in one patient. In another case the aqueous level of ketoconazole was 0.35 µg/ml. The vitreous in the same patient contained 0.71 µg/ml of the drug.