DIFFERENTIAL SENSITIVITIES OF 5 RAT HEPATOMA CELL LIES TO ANTI-CANCER DRUGS

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 38 (3), 656-660
Abstract
Permanent tumor cell lines (5) derived originally from either a solid or an ascites biopsy of rat hepatoma exhibited differential sensitivities to bleomycin, adriamycin, 1-.beta.-D-arabinofuranosylcytosine, hydroxyurea, 1-trans-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea. The cells were least sensitive to hydroxyurea and 1-.beta.-D-arabinofuranosylcytosine, with some cell lines being almost totally resistant to these drugs. From 25- to 700-fold differences in survival were obtained between cell lines treated with either bleomycin or adriamycin.