Role of Kidney in Pathogenesis of Experimental Nephrotic Hyperlipemia in Rats.

Abstract

The nephro-tic syndrome was produced in rats by the injection of nephro-toxic sera (NTS) obtained from rabbits. Bilateral nephrectomy prevented the development of hyperlipemia in rats injected with NTS. The degree of hyperlipemia in rats with chronic nephrotoxic renal disease was decreased progressively with the removal of each kidney. Production of unilateral renal disease in the presence of one normal kidney did not prevent the development of hyperlipemia. Lipemia was less, however, than in rats with bilateral disease. When the right nephrotic kidney was removed from rats with unilateral renal involvement, the serum cholesterol and total lipid values and the urinary protein content decreased to normal. Right nephrectomy in rats with bilateral renal disease, however, resulted in only slight decreases in these values which remained above the normal range. It is suggested that a."hyperlipemia-inducing" agent may be secreted by the nephrotic kidney.