Neurologic effects of tryptophan in patients receiving a monoamine oxidase inhibitor
- 2 December 1960
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 10 (12), 1076
- https://doi.org/10.1212/wnl.10.12.1076
Abstract
The oral administration of 20 to 50 mg of L-tryptophan per kilogram to 7 patients during therapy with a monoamine oxidase (MAO) inhibitor produced neurologic effects including ethanol-like intoxication, drowsiness, hyperreflexia, and clonus. The possible mediation of these effects by tryptamine and serotonin and implications in the clinical use of MAO inhibitors are discussed.Keywords
This publication has 4 references indexed in Scilit:
- Tryptophan Loading and Excretion of 5-Hydroxyindoleacetic Acid in Normal and Schizophrenic SubjectsScience, 1959
- THE EFFECT OF MONOAMINE OXIDASE INHIBITORS AND TRYPTOPHAN ON THE TRYPTAMINE CONTENT OF ANIMAL TISSUES AND URINE1959
- EFFECTS OF TRYPTAMINE ON THE CENTRAL NERVOUS SYSTEM, INCLUDING A PHARMACOLOGICAL PROCEDURE FOR THE EVALUATION OF IPRONIAZID-LIKE DRUGS1959
- PHARMACOLOGICAL STUDIES WITH THE SEROTONIN PRECURSOR, 5-HYDROXYTRYPTOPHAN1958