Dimorphism in bile salt/lecithin mixed micelles
- 1 January 1981
- journal article
- research article
- Published by American Chemical Society (ACS) in Biochemistry
- Vol. 20 (2), 415-418
- https://doi.org/10.1021/bi00505a029
Abstract
The dependence of certain properties of bile sale/lecithin mixed micelles on the molar ratio of the 2 components was investigated. UV absorption suggested that the micellar system is fundamentally altered on passing through a bile salt:lecithin ratio of 1.8:1. Differential scanning calorimetry confirmed this transition ratio; in addition, it indicated a bilayer arrangement of lecithin, in support of the mixed-disk model of micellar structure, but only for micelles having a molar ratio < 1.8:1. For micelles having larger ratios, which are those of physiological interest, calorimetry was inconsistent with the mixed-disk model. These observations support the X-ray structure analysis of Mueller.This publication has 3 references indexed in Scilit:
- Quasielastic light-scattering studies of aqueous biliary lipid systems. Mixed micelle formation in bile salt-lecithin solutionsBiochemistry, 1980
- The physical chemistry of cholesterol solubility in bile. Relationship to gallstone formation and dissolution in man.Journal of Clinical Investigation, 1978
- Phosphorus Assay in Column ChromatographyJournal of Biological Chemistry, 1959