Early postnatal hypoxia induces long-term changes in the dopaminergic system in rats
- 1 June 1993
- journal article
- Published by Springer Nature in Journal of Neural Transmission
- Vol. 93 (2), 109-121
- https://doi.org/10.1007/bf01245341
Abstract
A rat model of a mild, chronic, early postnatal hypoxia, characterized by long-term consequences in the behavioural outcome, was used to study longterm consequences in the dopaminergic system. Exposure of newborn rats to an early postnatal hypoxia (hypobaric hypoxia, 11 kPa pO2 in the inspiratory air, 2nd–10th day of life, 10 hours daily) brings about the following lasting neurochemical changes: an increased stimulated dopamine release rate from striatum slices by about 30%, an increased low affinity, high capacity dopamine uptake into striatum synaptosomes by about 100%. The critical period to produce an increased release rate of dopamine was estimated as day 2–6 postnatally. There are no long-term changes in the concentration of dopamine and its metabolites and in the tyrosine hydroxylase activity in consequences of this early postnatal hypoxia. Treatment of newborn animals with L-DOPA (10–50 μg/g body weight) previous to hypoxia normalizes the DA release rate.Keywords
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