Sensory hair cells of a fish ear: evidence of multiple types based on ototoxicity sensitivity

Abstract

Sensory hair cells from the striolar region (striolar hair cells) of the utricle and the lagena of the ear of a teleost fish Astronotus ocellatus (Cuvier) ear are sensitive to gentamicin sulphate, an ototoxic drug. In contrast, sensory hair cells from outside the striolar region (extra-striolar hair cells) are not sensitive to gentamicin. These data, combined with results from studies showing different ultrastructural features and different immunoreactivity to a calcium binding protein, S-100, lead to the suggestion that there are distinguishable types of hair cells in these endorgans. These results add to the increasing evidence that classifying the sensory hair cells of fish ears only as the traditional `vestibular type II' may be inadequate for properly understanding structure and function of the fish ear.