Ag(c): recognition by a monoclonal antibody.
- 1 May 1986
- journal article
- research article
- Published by Wolters Kluwer Health in Arteriosclerosis: An Official Journal of the American Heart Association, Inc.
- Vol. 6 (3), 341-344
- https://doi.org/10.1161/01.atv.6.3.341
Abstract
A monoclonal antibody directed against human apolipoprotein B, which was previously shown in family studies to detect allelic variations (J Biol Chem 1984; 259:6423-6430), has now been identified with the Ag(c) factor. This identification allows the location of the Ag system on the structural gene for apolipoprotein B and on the short arm of human chromosome 2. The epitope corresponding to Ag(c) is located within the amino acid sequence common to apolipoproteins B-100 and B-48. Since a single molecule of apolipoprotein B-100 is present on human LDL, individual LDL possesses either the epitope corresponding to Ag(c) or that corresponding to Ag(g). These studies on allelic variation among human apolipoprotein B species parallel similar studies in animals in which a relationship to atherosclerosis was found.This publication has 11 references indexed in Scilit:
- Molecular weights of apoprotein B obtained from human low-density lipoprotein (apoprotein B-PI) and from rat very low density lipoprotein (apoprotein B-PIII)Biochemistry, 1985
- Low density lipoprotein metabolism in hypertriglyceridemic and normolipidemic patients with coronary heart disease.Journal of Lipid Research, 1985
- Anti-apoprotein B monoclonal antibodies detect human low density lipoprotein polymorphism.Journal of Biological Chemistry, 1984
- Composition and distribution of low density lipoprotein fractions in hyperapobetalipoproteinemia, normolipidemia, and familial hypercholesterolemia.Proceedings of the National Academy of Sciences, 1983
- Immunochemical heterogeneity of human plasma apolipoprotein B. I. Apolipoprotein B binding of mouse hybridoma antibodies.Journal of Biological Chemistry, 1982
- Immunogenetic study on the polymorphism of serum ?2-lipoproteins in mink. IV. Diallelism at the Ld locus of low-density lipoproteinBiochemical Genetics, 1981
- Normotriglyceridemic abetalipoproteinemia. absence of the B-100 apolipoprotein.JCI Insight, 1981
- Heterogeneity of apolipoprotein B: isolation of a new species from human chylomicrons.Proceedings of the National Academy of Sciences, 1980
- Rhesus Monkey (Macaca mulatta) AllotypesInternational Archives of Allergy and Immunology, 1979
- Ag(i): Detection of an Antithetical Factor to Ag(h)Vox Sanguinis, 1974