The mammalian Mediator complex
- 24 November 2004
- journal article
- review article
- Published by Wiley in FEBS Letters
- Vol. 579 (4), 904-908
- https://doi.org/10.1016/j.febslet.2004.11.031
Abstract
The multiprotein Mediator (Med) complex is an evolutionarily conserved transcriptional regulator that plays important roles in activation and repression of RNA polymerase II transcription. Prior studies identified a set of more than twenty distinct polypeptides that compose the Saccharomyces cerevisiae Mediator. Here we discuss efforts to characterize the subunit composition and associated activities of the mammalian Med complexKeywords
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