Amyloidosis in experimental murine alveolar hydatidosis

Abstract

Male mice (eight to ten weeks old, C57BL/6J, H-2b strain) were inoculated intraperitoneally with 50 Echinococcus multilocularis cysts each and killed 12 and 17 weeks later. The alveolar cyst masses were weighed and the spleens and kidneys fixed for light and electron microscopy of sections. Amorphous eosinophilic deposits in both were extensive and there were apple-green birefringent deposits visible under polarized light in all the glomeruli. The presence of amyloid was confirmed by electron microscopy.