L-.BETA.-(5-Hydroxy-2-pyridyl)-alanine and L-.BETA.-(3-hydroxyureido)-alanine from streptomyces.

Abstract

A chemical screening study on the metabolites from actinomycetes revealed 2 unusual amino acids: L-.beta.-(5-Hydroxy-2-pyridyl)-alanine (1) and L-.beta.-(3-hydroxyureido)-alanine (9). The structures of 1 and 9 were elucidated from the physico-chemical properties of these amino acids and derivatives, and supported by synthesis. Antibacterial activities of 1 and its methylester were antagonized by L-tyrosine and those of 9 and its derivative by L-glutamine.