Increased Incidence of Nontasters of Phenylthiocarbamide among Congenital Athyreotic Cretins

Abstract

The incidence of nontasters for phenylthiocarbamide was found to be significantly higher in 27 athyreotic cretins than in normal adults and children. A significant increase of nontasters among the parents and siblings of these cretins was also found. These findings are discussed in relation to maldevelopment of the fetal thyroid in nontaster genotypes.