Dietary Vitamin-a Deficiency: Effects on Growth, Infection, and Mortality

Abstract

Vitamin A (VA) has been experimentally linked in animals to growth in weight, host resistance to infection, and survival for nearly eight decades. These consistent findings appear to have their human correlate. VA-deficient children are more likely to have comorbidity and to be stunted in growth, and they have a higher risk of mortality. In several large field trials VA supplementation has reduced mortality by >= 30%. Presumably a similar or greater public health impact can be achieved by improving dietary VA intake. The relation between dietary imbalance and VA deficiency starts at a young age. Early cessation of breast-feeding, poor quality of the weaning diet, and infrequent consumption of VA-rich foods appear to underlie mild xerophthalmia. These dietary imbalances often coexist with food access. We must know how to alter detrimental food habits before dietary interventions can be formulated. Improving dietary quality to enhance VA nutriture will likely carry numerous other nutritional benefits to children.