Characterization of Nucleic Acids by Nanopore Analysis
Top Cited Papers
- 27 September 2002
- journal article
- review article
- Published by American Chemical Society (ACS) in Accounts of Chemical Research
- Vol. 35 (10), 817-825
- https://doi.org/10.1021/ar000138m
Abstract
Single-stranded DNA and RNA molecules in solution can be driven through a nanoscopic pore by an applied electric field. As each molecule occupies the pore, a characteristic blockade of ionic current is produced. Information about length, composition, structure, and dynamic motion of the molecule can be deduced from modulations of the current blockade.Keywords
This publication has 21 references indexed in Scilit:
- Sequence-specific detection of individual DNA strands using engineered nanoporesNature Biotechnology, 2001
- Rapid discrimination among individual DNA hairpin molecules at single-nucleotide resolution using an ion channelNature Biotechnology, 2001
- Rapid nanopore discrimination between single polynucleotide moleculesProceedings of the National Academy of Sciences, 2000
- Stochastic Sensing with Protein PoresAdvanced Materials, 2000
- Microsecond Time-Scale Discrimination Among Polycytidylic Acid, Polyadenylic Acid, and Polyuridylic Acid as Homopolymers or as Segments Within Single RNA MoleculesBiophysical Journal, 1999
- Polymer translocation through a holeThe Journal of Chemical Physics, 1999
- Driven Polymer Translocation Through a Narrow PoreBiophysical Journal, 1999
- Characterization of individual polynucleotide molecules using a membrane channelProceedings of the National Academy of Sciences, 1996
- Dynamics and Free Energy of Polymers Partitioning into a Nanoscale PoreMacromolecules, 1996
- Counting polymers moving through a single ion channelNature, 1994