Deduction of duodenal ulcer recurrence by healing with cimetidine plus sulpiride.
Open Access
- 1 December 1986
- Vol. 27 (12), 1512-1515
- https://doi.org/10.1136/gut.27.12.1512
Abstract
The effect of combined treatment with sulpiride plus cimetidine was compared against that of cimetidine alone on the healing of duodenal ulcer and on the subsequent relapse rate. In a double blind study, 35 patients with duodenal ulcer diagnosed by endoscopy were randomly assigned to receive cimetidine 800 mg daily and 38 patients to receive cimetidine 800 mg plus sulpiride 200 mg daily. Sixty patients whose ulcers were healed at three months continued to be observed after stopping treatment and underwent endoscopy to detect recurrences when symptomatic or at three and at six months if asymptomatic. Recurrence was observed in 18 (72%) of 25 patients whose ulcers had healed on cimetidine alone, but in only 11 (38%) of 29 patients whose ulcers healed on cimetidine plus sulpiride.This publication has 17 references indexed in Scilit:
- Prevention of duodenal ulcers in the rat using a combination of ranitidine and sucralphate in subtherapeutic doses.Gut, 1985
- A controlled study comparing cimetidine treatment to an intensive antacid regimen in the therapy of uncomplicated duodenal ulcerDigestive Diseases and Sciences, 1979
- TREATMENT OF DUODENAL-ULCER WITH ANTACID AND SULPIRIDE - DOUBLE-BLIND CONTROLLED-STUDY1979
- Prophylactic effect of cimetidine in duodenal ulcer disease.BMJ, 1978
- Relapse of duodenal ulceration after cimetidine treatment.BMJ, 1978
- Inhibition of gastrin secretion by sulpiride treatment in duodenal ulcer patientsGastroenterology, 1978
- Cimetidine versus intensive antacid therapy for duodenal ulcer: a multicenter trial.1978
- MAINTENANCE TREATMENT OF RECURRENT PEPTIC ULCER BY CIMETIDINEThe Lancet, 1978
- Perforation of chronic peptic ulcers after cimetidine.BMJ, 1977
- Smoking and cancer of the alimentary tract in Poland.British Journal of Cancer, 1969