Reproductive counselling for multiple sclerosis patients

Abstract

The diagnosis of multiple sclerosis (MS) is frequently made during the reproductive years, and there is increasing evidence that it has a genetic causal component. An increasing number of couples are concerned about recurrence and they request reproductive counselling at genetic clinics or from their physicians. Here we outline factors to be considered in the reproductive counselling of such individuals. These include (1) empiric recurrence risks, (2) the effect of pregnancy and delivery on maternal MS, (3) overall pregnancy outcome, (4) longterm prognosis for the affected parent, and (5) the possibility of sexual dysfunction in couples trying to conceive a child.