EFFECTS OF PURIFIED ANTERO-PITUITARY HORMONES ON THE CARBOHYDRATE STORES OF HYPOPHYSECTOMIZED RATS

Abstract

Myo-glycostatic activity is greatest in crude extracts of the ant. hypophysis and in highly purified growth promoting extracts. Thyrotrophic extracts known to be impure had activities no greater than to be expected from possible growth hormone contamination. Adrenocorticotrophic hormone showed slight or no activity during the one day test in which growth hormone preps. were highly effective. However, when through longer adm. of adrenocorticotrophic hormone, the adrenal gland becomes normal or hypertrophied, muscle glycogen and hepatic glycogen are maintained by it during fasting. Pure lactogenic hormone is ineffective in the one day myoglycostatic test or when administered for 4 or 14 days.