Acute Meprobamate Poisoning
- 9 October 1958
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 259 (15), 716-718
- https://doi.org/10.1056/nejm195810092591504
Abstract
MEPROBAMATE, or 2-methyl-2-n-propyl-1,3-propanediol dicarbamate, is a tranquilizing drug that has become widely used in the short time since its synthesis in 1950.1 It has been proved to be of particular value in anxiety and tension states and numerous related conditions.2 It has also been used to good advantage in various types of skeletal-muscle spasm.3 The pharmacology of meprobamate has been worked out largely by Berger,4 , 5 according to whom it shows three properties of special interest: a muscle-relaxant action; an anticonvulsant action; and a taming effect on monkeys. The muscle-relaxant action affects only voluntary skeletal muscles. The diaphragm, however, is relatively . . .Keywords
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