ROLE OF H-2 LYMPHOCYTE-DEFINED AND SEROLOGICALLY-DEFINED COMPONENTS IN THE GENERATION OF CYTOTOXIC LYMPHOCYTES
Open Access
- 1 November 1974
- journal article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 140 (5), 1410-1415
- https://doi.org/10.1084/jem.140.5.1410
Abstract
The cell-mediated lympholytic capability of mouse spleen cells stimulated in mixed lymphocyte culture is determined by lymphocyte-defined (LD) and serologically-defined (SD) antigenic differences present during sensitization. Cells which are activated by LD differences alone are markedly less effective in causing lysis of target cells. This lack of cytotoxicity is shown to be, at least in part, due to the inability of LD differences to allow the efficient generation of cytotoxic lymphocytes. SD antigens not only serve as good targets for CML but are also shown to be important for the generation of cytotoxic lymphocytes during the mixed lymphocyte culture.Keywords
This publication has 15 references indexed in Scilit:
- Demonstration by MLR test of a previously unsuspected intra-H-2 crossover in the B10.HTT strain: implications concerning location of MLR determinants in the Ir region.1973
- The involvement of LD- and SD-region differences in MLC and CML: a three-cell experiment.1973
- GENERATION OF CYTOTOXIC LYMPHOCYTES IN MIXED LYMPHOCYTE REACTIONSThe Journal of Experimental Medicine, 1973
- CELL-MEDIATED LYMPHOLYSISThe Journal of Experimental Medicine, 1973
- Cell Mediated Immunity: Separation of Cells Involved in Recognitive and Destructive PhasesScience, 1973
- SEROLOGICALLY DEFINED AND LYMPHOCYTE-DEFINED COMPONENTS OF THE MAJOR HISTOCOMPATIBILITY COMPLEX IN THE MOUSEThe Journal of Experimental Medicine, 1972
- Mixed lymphocyte culture reactivity and H-2 histocompatibility loci differencesCellular Immunology, 1972
- ALLOGENEIC AND XENOGENEIC RESPONSE IN MIXED LEUKOCYTE CULTURESThe Journal of Experimental Medicine, 1972
- The H-2 Model for the Major Histocompatibility SystemsImmunological Reviews, 1971
- Strain C57BL-10ScSn and its congenic resistant sublines.1970