Mitogen and muscle extract induced in vitro proliferative responses in myasthenia gravis, dermatomyositis, and polymyositis.
Open Access
- 1 June 1975
- journal article
- research article
- Published by BMJ in Journal of Neurology, Neurosurgery & Psychiatry
- Vol. 38 (6), 521-524
- https://doi.org/10.1136/jnnp.38.6.521
Abstract
We have compared the lymphocyte in vitro proliferative response induced by muscle extract, phytohaemagglutinin, and pokeweed mitogen in peripheral blood lymphocytes of patients with myasthenia gravis, polymyositis, dermatomyositis, and normal subjects. Similar mean responses to antigen and mitogen were seen in cells of all groups of patients. The proliferative responses induced by muscle did not differ in thymic cells from myasthenics as compared with those from cardiac surgery controls. Our findings do not support the hypothesis that cell-mediated immunity to muscle or major impairment of lymphocyte responses to mitogens occurs in these diseases.Keywords
This publication has 15 references indexed in Scilit:
- The Thymus in Myasthenia GravisNew England Journal of Medicine, 1974
- Cell-Mediated Immunity in PolymyositisArchives of Neurology, 1974
- Thymic lymphocyte function in myasthenia gravisNeurology, 1973
- Cell-Mediated Cytotoxicity to Muscle in PolymyositisNew England Journal of Medicine, 1973
- Studies in Myasthenia Gravis: Cellular Hypersensitivity to Skeletal MuscleAmerican Journal of Clinical Pathology, 1972
- Lymphotoxin formation by lymphocytes and muscle in polymyositisJCI Insight, 1972
- Immunologic Significance of In Vitro Lymphocyte ResponsesMedical Clinics of North America, 1972
- Sensitized lymphocytes in muscular dystrophy: evidence for a neural factor in pathogenesisJournal of Neurology, Neurosurgery & Psychiatry, 1971
- In Vitro Approaches to the Mechanism of Cell-Mediated Immune ReactionsAdvances in Immunology, 1971
- Human Lymphocyte Migration as a Parameter of HypersensitivityActa Medica Scandinavica, 1967