Fluorescence Behavior of 7-Substituted Coumarin Derivatives by Inclusion Complexation with β-Cyclodextrin
Open Access
- 1 January 1983
- journal article
- research article
- Published by Pharmaceutical Society of Japan in YAKUGAKU ZASSHI
- Vol. 103 (2), 193-197
- https://doi.org/10.1248/yakushi1947.103.2_193
Abstract
The inclusion complexes of 7-substituted coumarin derivatives (7-hydroxy-, 7-amino-, 7-dimethylamino-, 7-methoxy- and 7-ethoxy-4-methylcoumarins) with .beta.-cyclodextrin in aqueous solutions were formed. The equilibrium constants of these complexes were obtained by fluorescence and circular dichroism spectrophotometric methods. Fluorescence enhancement or quenching occurred upon inclusion of coumarin derivatives with .beta.-cyclodextrin. The fluorescent behavior was discussed from the standpoint of the solvent effect of coumarin derivatives and of the geometry of the inclusion complexes assumed from their 1H NMR spectra.Keywords
This publication has 1 reference indexed in Scilit:
- Interaction of Cyclodextrins with Fluorescent Probes and Its Application to Kinetic Studies of AmylaseThe Journal of Biochemistry, 1976