Research investigating application of the Minnesota Multiphasic Personality Inventory (MMPI) to schizophrenia is reviewed. This review is organized into five sections: diagnostic issues in schizophrenia; methodological considerations in MMPI research on schizophrenia; historical overview of MMPI research on schizophrenia; current topics in MMPI research on schizophrenia; conclusion. Recommendations are offered for future research and clinical application of research findings.