Disturbed Pubertal Growth in Girls Treated for Acute Lymphoblastic Leukemia
- 1 January 1987
- journal article
- research article
- Published by Taylor & Francis in Pediatric Hematology and Oncology
- Vol. 4 (1), 1-5
- https://doi.org/10.3109/08880018709141243
Abstract
Pubertal growth was studied in 10 girls previously treated for acute lymphoblastic leukemia. The average age at menarche was 12.2 years, which is significantly lower (p < 0.01) than the expected 13.1 years. Compared with normal girls, these girls showed a subnormal (p < 0.05) peak height velocity during the second year before menarche. The remaining growth before menarche as well as the total postmenarchal growth was close to the normal average. The average final standing height was 1 SD less than what would be expected from their height 1 year after the cessation of therapy. A relative growth hormone deficiency in combination with early onset of puberty could account for this loss in final height.Keywords
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