Enzyme circadian rhythms and conformational oscillators survey and prospects
- 1 February 1991
- journal article
- research article
- Published by Taylor & Francis in Journal of Interdisiplinary Cycle Research
- Vol. 22 (1), 41-55
- https://doi.org/10.1080/09291019109360098
Abstract
An unconventional hypothesis is proposed combining for the first time two different features which are basic for cell metabolism but have been as yet investigated separately: (a) circadian rhythms in enzyme activity, which play a fundamental role in adaptation to the 24h cyclities of environmental cues, and (b) the dynamic character of protein structure which results in continuous shifting between conformational states. Recent data indicate that large time‐scale (hours, circadian) periodicities can thus arise spontaneously in the catalytic characteristics of enzymes in solution, alternating phases of high and low sensitivity to substrate and effectors. The question raises whether conformational oscillators would provide a molecular component of the processes which govern rhythmicity of enzyme activity. This hypothesis also opens a new approach to the study of the temporal organization of enzyme‐enzyme interactions and metabolic channeling, particularly in photoperiodism.Keywords
This publication has 43 references indexed in Scilit:
- Transcriptional Regulation by a Circadian RhythmPlant Cell, 1989
- Diurnal and Circadian Rhythms in the Accumulation and Synthesis of mRNA for the Light-Harvesting Chlorophyll a/b-Binding Protein in TobaccoPlant Physiology, 1988
- Dynamic spatial distribution of proteins in the cellTrends in Biochemical Sciences, 1988
- Are Spontaneous Conformational Interconversions a Molecular Basis for Long-Period Oscillations in Enzyme Activity?Chronobiology International, 1988
- Microheterogeneity of the malate dehydrogenase from several sourcesBiochemical and Biophysical Research Communications, 1987
- Circadian rhythmicity of protein synthesis and translational control inEuglena gracilisJournal of Interdisiplinary Cycle Research, 1986
- Phosphorylation - dephosphorylation process as a probable mechanism for the diurnal regulatory changes of phosphoenolpyruvate carboxylase in CAM plantsBiochemical and Biophysical Research Communications, 1986
- Diurnal changes in the properties of phosphoenolpyruvate carboxylase in Bryophyllum leaves: a possible co valent modificationFEBS Letters, 1984
- Cyclic activity of L‐asparaginase through reversible phosphorylation in Leptosphaeria michotiiFEBS Letters, 1984
- The effect of different inhibitors of transcription and translation on the expression and control of circadian rhythm in individual cells of AcetabulariaExperimental Cell Research, 1975