Overview: efficacy and safety of the rapid neuroleptization method with injectable haloperidol

Abstract

The literature on the rapid neuroleptization (titration) method with i.m. haloperidol is reviewed. Most of the approximately 650 predominantly schizophrenic and manic patients represented in the studies calmed down rapidly on medication, and some demonstrated an early reduction in core psychotic symptoms. The initial doses varied widely, ranging from 1 to 30 mg, with a maximum total daily dosage of 100 mg. The medication seemed to have been well tolerated in all cases, with no reported major complications. The method evidently shows merit with agitated and belligerent patients. A number of specific recommendations are made for further research to clearly establish the effectiveness and safety of this method of neuroleptic administration.