Ocular Infection With Herpes Simplex Virus in Nonimmune and Immune Mice
- 1 June 1983
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Ophthalmology (1950)
- Vol. 101 (6), 961-964
- https://doi.org/10.1001/archopht.1983.01040010961023
Abstract
• In a detailed study of ocular infection by herpes simplex virus (HSV) type 1 in mice, the course and signs of eye disease were investigated and compared in primary and secondary infection using slit-lamp examination, culture of the tear film, and monitoring of the blink reflex. Response to primary inoculation ranged from subclinical infection to severe keratitis. Compared with conjunctival scarification, corneal scarification resulted in more frequent and severe eye disease and signs of CNS infection. Previous infection in the skin of the contralateral ear considerably modified subsequent infection of the eye so that signs of disease occurred earlier, were limited to dendritic keratitis with some stromal involvement, and were largely reversible. The mouse seems to be a suitable animal for studying ocular infection with HSV.This publication has 14 references indexed in Scilit:
- Experimental ulcerative herpetic keratitis. I. Systemic immune responses and resistance to corneal infection.British Journal of Ophthalmology, 1981
- Cell-mediated Immunity in Herpes Simplex Virus-infected Mice: Functional Analysis of Lymph Node Cells During Periods of Acute and Latent Infection, with Reference to Cytotoxic and Memory CellsJournal of General Virology, 1980
- Strain Specificity of Clinical Isolates of Herpes Simplex VirusArchives of Ophthalmology (1950), 1980
- Prostaglandins Enhance Spread of Herpes Simplex Virus in Cell CulturesJournal of General Virology, 1978
- Central Nervous System Susceptibility to Herpes Simplex InfectionJournal of Neuropathology and Experimental Neurology, 1978
- Neural spread of herpes simplex virus types 1 and 2 in mice after corneal or subcutaneous (footpad) inoculationJournal of the Neurological Sciences, 1978
- Acute and Recurrent Infection with Herpes Simplex Virus in the Mouse: a Model for Studying Latency and Recurrent DiseaseJournal of General Virology, 1975
- Spontaneous Reactivation of Experimental Herpes Simplex Keratitis in RabbitsArchives of Ophthalmology (1950), 1967
- Fluorescent Antibody Localization of Herpes Simplex Virus in the ConjunctivaArchives of Ophthalmology (1950), 1965
- Observations on Herpetic Keratitis and KeratoconjunctivitisArchives of Ophthalmology (1950), 1956