A Search for the Mechanism Underlying the Altered MCV in Thyroid Dysfunction: A Study of Serum and Red Cell Membrane Lipids

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Abstract
The mean red cell volume (MCV) is increased in hypo- and decreased in hyperthyroidism but the underlying cause(s) is unkwown. In view of the well recognized alternations in serum lipids in thyroid dysfunction, the possibility was examined that a corresponding alteration in the amount or distribution of lipids in the red cell membrane may account for the red cell volume changes. This hypothesis was not supported.