Polypeptide-Binding Membrane Receptors: Analysis and Classification
- 3 April 1981
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 212 (4490), 14-20
- https://doi.org/10.1126/science.6259730
Abstract
Polypeptide receptors on mammalian plasma membranes can be categorized on the basis of function. The binding of ligand by class I receptors results in changes in cell metabolism or behavior. Hormone-receptor interactions typify this group. The binding of ligand by class II receptors in ligand internalization. Although changes in cellular activity may result from metabolism of the internalized ligand, the interaction between ligand and class II receptor does not itself lead to alterations in cell behavior. Class II receptors include those for low-density lipoproteins and for alpha-macroglobulin-protease complexes. Although receptors within each category are chemically disparate, they show striking similarities in behavior. Analysis of the behavioral patterns of receptors in each category reveals insights into receptor physiology and allows for a prospective analysis of receptor characteristics.Keywords
This publication has 67 references indexed in Scilit:
- Receptor-mediated pinocytosis of mannose glycoconjugates by macrophages: Characterization and evidence for receptor recyclingCell, 1980
- Evidence for reutilization of surface receptors for α-macroglobulin · protease complexes in rabbit alveolar macrophagesCell, 1980
- Fate of plasma membrane during endocytosis. II. Evidence for recycling (shuttle) of plasma membrane constituentsThe Journal of cell biology, 1979
- Ferrocyanide staining of transferrin and ferritin-conjugated antibody to transferrin.Journal of Histochemistry & Cytochemistry, 1979
- Membrane economics in endocytic systemsJournal of Theoretical Biology, 1977
- Thyrotropin-releasing hormone regulates the number of its own receptors in the GH3 strain of pituitary cells in cultureBiochemistry, 1975
- Rates of Colloid Droplet and Apical Vesicle Production and Membrane Turnover During Thyroglobulin Secretion and ResorptionEndocrinology, 1973
- EVIDENCE FOR RECYCLING OF SYNAPTIC VESICLE MEMBRANE DURING TRANSMITTER RELEASE AT THE FROG NEUROMUSCULAR JUNCTIONThe Journal of cell biology, 1973
- PINOCYTOSIS IN ACANTHAMOEBA CASTELLANII The Journal of cell biology, 1972
- Defective metabolism of vitamin B12 in fibroblasts from children with methylmalonicaciduriaBiochemical and Biophysical Research Communications, 1971