Oxidation of Ergosterol by Rat and Mouse Liver Mitochondria.
- 1 April 1961
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 106 (4), 704-708
- https://doi.org/10.3181/00379727-106-26448
Abstract
Oxidation of ergosterol-28-C14 and of ergosterol-U-C14 by mitochondrial preparations from rat or mouse livers was investigated. Either substrate yielded C14O2. Ergosterol-U-C14 yielded radioactive neutral and acidic products, while ergosterol-28-C14 gave only neutral radioactive material. Among the acidic products obtained from ergosterol-U-C14 was a radioactive acid with Rf close to that of trihydroxycoprostanic acid. Similarities between the oxidation of cholesterol and ergosterol by liver mitochondria in vitro suggest that enzyme systems involved are closely related to each other, if not identic al.Keywords
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