Interaction of origin binding protein with an origin of replication of herpes simplex virus 1.
- 1 May 1988
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 85 (9), 2959-2963
- https://doi.org/10.1073/pnas.85.9.2959
Abstract
Herpes simplex virus 1 encodes a protein that binds specifically to a viral DNA replication origin (oris). This origin-binding protein has been purified to homogeneity by means of sequence-specific DNA affinity chromatography. The purified origin-binding protein, which has a molecular weight of 83,000, interacts with both parts of the oris dyad; however, the affinity for the two sites differs by an order of magnitude. The sequence TTCGCA occurs as a nearly perfect direct repeat within the two sites and may constitute the recognition sequence for the origin-binding protein.This publication has 22 references indexed in Scilit:
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