The use of the novel substrate–heme complex approach in the derivation of a representation of the active site of the enzyme complex 17α-hydroxylase and 17,20-lyase
- 9 April 2004
- journal article
- Published by Elsevier in Biochemical and Biophysical Research Communications
- Vol. 316 (3), 595-598
- https://doi.org/10.1016/j.bbrc.2004.02.092
Abstract
No abstract availableKeywords
This publication has 4 references indexed in Scilit:
- Mechanism of 17α-Hydroxylase/17,20-Lyase — An initial geometric perspective for the Lyase of the C(17)C(20) bond of C21 steroidsBioorganic & Medicinal Chemistry Letters, 1998
- Incorporation of label from18O2into acetate during side-chain cleavage catalysed by cytochrome P-45017α(17α-hydroxylase-17,20-lyase)Journal of the Chemical Society, Perkin Transactions 1, 1994
- A molecular model for the enzyme cytochrome P45017α, a major target for the chemotherapy of prostatic cancerBiochemical and Biophysical Research Communications, 1990
- Inhibition of testicular 17α-hydroxylase and 17,20-lyase but not 3β-hydroxysteroid dehydrogenase-isomerase or 17β-hydroxysteroid oxidoreductase by ketoconazole and other imidazole drugsThe Journal of Steroid Biochemistry and Molecular Biology, 1987