SRP meets the ribosome
- 2 November 2004
- journal article
- review article
- Published by Springer Nature in Nature Structural & Molecular Biology
- Vol. 11 (11), 1049-1053
- https://doi.org/10.1038/nsmb853
Abstract
Cotranslational targeting directly couples synthesis of proteins to their translocation across or insertion into membranes. The signal recognition particle (SRP) and its membrane-bound receptor facilitate the targeting of the translation machinery, the ribosome, via recognition of a signal sequence in the nascent peptide chain. By combining structures of free and ribosome-bound SRP we derive a structural model describing the dynamic nature of SRP when it meets the ribosome.Keywords
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