The acute phase response to injury and its relationship to changes in endoplasmic reticulum of rat liver

Abstract

Induction of the acute phase response to injury was accompanied by dilation and loss of the regular structural features of the endoplasmic reticulum membranes of rat liver. There were increases in sialyltransferase (EC 2.4.99.1) and galactosyltransferase (EC 2.4.1.22), protein-bound sialic acid and galactose, and protein, RNA, and phospholipid in microsome fractions of liver after experimental injury. It is suggested that the ultrastructural and biochemical changes in liver result in part from an increased demand for liver-synthesized glycoproteins.