Enhanced chemotaxis of tumor‐derived and virus‐transformed cells to fibronectin and fibroblast‐conditioned medium
- 15 January 1984
- journal article
- research article
- Published by Wiley in International Journal of Cancer
- Vol. 33 (1), 43-48
- https://doi.org/10.1002/ijc.2910330109
Abstract
SV40 transformants of human embryo fibroblasts showed an enhanced chemotactic response to fibronectin and conditioned medium of fibroblasts in comparison to the non‐transformed cells. An even higher chemotactic response was characteristic for a malignant human fibrosarcoma cell line, whereas cells derived from low‐grade malignant dermatofibrosarcoma showed a normal response in the Boyden chamber assay. The high stimulation of chemotaxis is paralleled by a reduced synthesis and an altered deposition of fibronectin in the pericellular matrix of these cells. Both high chemotactic response and lack of deposition of fibronectin may play a role in tissue invasion and formation of metastasis by malignant tumors.This publication has 39 references indexed in Scilit:
- Synthesis of type IV collagen and laminin in cultures of skeletal muscle cells and their assembly on the surface of myotubesDevelopmental Biology, 1982
- Chemotactic responses of fibroblasts to tropoelastin and elastin-derived peptides.JCI Insight, 1982
- Responses of normal and malignant cells to collagen, collagen-derived peptides and the C5-related tumor cell chemotactic peptideCell Differentiation, 1981
- Collagen and Collagen-derived Fragments Are Chemotactic for Tumor CellsJCI Insight, 1981
- Metastatic potential correlates with enzymatic degradation of basement membrane collagenNature, 1980
- Synthesis of collagen by human fibroblasts and their SV40 transformantsExperimental Cell Research, 1980
- Type III procollagen is the major collageneous component produced by a continuous rhabdomyosarcoma cell lineFEBS Letters, 1979
- Initial adhesion of human fibroblasts in serum-free medium: Possible role of secreted fibronectinCell, 1979
- Antigenic structure of the aminoterminal region in type I procollagen: Characterization of sequential and conformational determinantsImmunochemistry, 1976
- Cell Migration in Early Vertebrate Development Studied in Interspecific ChimerasPublished by Wiley ,1976