Effect of 2,4-Dinitrophenol on Magnesium Metabolism.

Abstract

Summary After receiving interscapular injections of 2,4-dinitrophenol, 10 mg/kg daily for 4 days, rabbits were killed on the fifth day. The balance data revealed no significant changes except an increase in body weight. The relative specific activity of Mg²⁸, determined 4 hours after intravenous injection of Mg²⁸, was significantly increased in the kidney, heart, stomach, liver, lung, bone marrow, skin, brain, and bone cortex. The increased turnover of magnesium in these tissues is attributed to the increased rate of oxidation caused by 2,4-dinitrophenol.