Preparation and characterization of ?-cyclodextrin and poly(acrylic acid) microspheres
- 1 January 1998
- journal article
- research article
- Published by Taylor & Francis in Journal of Microencapsulation
- Vol. 15 (5), 629-637
- https://doi.org/10.3109/02652049809008246
Abstract
A method for the preparation of poly(acrylic acid) (PAA) microspheres cross-linked with beta-cyclodextrin (β-CD) is described. The method is based on a water-in-oil (w/o) emulsion solvent evaporation technique which facilitates a condensation reaction between PAA and β-CD. Aqueous solutions of PAA and β-CD were used as the dispersed phase and food grade olive oil was used as the continuous phase. The effect of homogenization speed (used in the preparation of the emulsion), phase volume ratio and cyclodextrin-polymer load on the particle size of the microspheres produced was investigated in a replicated factorial design. Microspheres were sized by light microscopy. The particle size of the microspheres was influenced by all three variables with two significant first order interactions between the variables being observed (homogenization speed with phase volume ratio and homogenization speed with load). A second order interaction between the three principal factors was also observed. Particle size ranged from 16 to 150m, depending on the production variables employed. The yield for the technique was 69.5 × 9.5%. Using selected conditions, microspheres of 15–25 pm size were prepared from a range of PAA with different weight average molecular weights (w). These particles were then characterized for β-CD, free carboxylic acid group content and residual oleic acid.Keywords
This publication has 6 references indexed in Scilit:
- Chitosan microspheres of nifedipine and nifedipine-cyclodextrin inclusion complexesInternational Journal of Pharmaceutics, 1996
- Microspheres and nanoparticles used in ocular delivery systemsAdvanced Drug Delivery Reviews, 1995
- Preparation of Three-Month Depot Injectable Microspheres of Leuprorelin Acetate Using Biodegradable PolymersPharmaceutical Research, 1994
- Particle size and size distribution of albumin microspheres produced by heat and chemical stabilizationInternational Journal of Pharmaceutics, 1989
- Nasal administration of gentamicin using a novel microsphere delivery systemInternational Journal of Pharmaceutics, 1988
- Variability in the phenol-sulphuric acid assay for sodium carboxymethylcelluloseInternational Journal of Pharmaceutics, 1986