Prevalence of Elevated Troponin I in End‐stage Renal Disease Patients Receiving Hemodialysis
- 1 September 2004
- journal article
- review article
- Published by Wiley in Academic Emergency Medicine
- Vol. 11 (9), 979-981
- https://doi.org/10.1197/j.aem.2004.03.022
Abstract
Patients with end-stage renal disease (ESRD) who are receiving hemodialysis have an increased incidence of atherosclerotic heart disease. Currently, there is considerable controversy regarding the significance of elevated cardiac troponin I (cTnI) levels in patients with ESRD. The objective of this study was to examine the prevalence of elevated cTnI levels in asymptomatic patients with ESRD on hemodialysis. This was a prospective cohort study at an urban hospital outpatient dialysis center. Serum was collected pre- and postdialysis from patients on dialysis at this center over a two-week period. Samples were batched and analyzed for cTnI using the Asxym fluorescent antibody test. An elevated cTnI level was defined as >0.8 ng/dL. Predialysis cTnI levels ranged from 0.8 ng/dL. cTnI levels are not falsely elevated in patients with ESRD on hemodialysis. In a patient with ESRD, myocardial injury should be suspected if his or her cTnI level is >0.8 ng/dL.Keywords
This publication has 10 references indexed in Scilit:
- European Society of Cardiology and American College of Cardiology guidelines for redefinition of myocardial infarction: How to use existing assays clinically and for clinical trialsAmerican Heart Journal, 2002
- Tissue specificity of cardiac troponin I, cardiac troponin T and creatine kinase-MBClinica Chimica Acta; International Journal of Clinical Chemistry, 1999
- Cardiac troponin elevations in chronic renal failure: prevalence and clinical significanceClinical Biochemistry, 1999
- Cardiac Troponins in Patients with Renal DysfunctionAnnals of Clinical Biochemistry: International Journal of Laboratory Medicine, 1998
- Specificity of Cardiac Troponin I and Creatine Kinase-MB Isoenzyme in Asymptomatic Long-Term Hemodialysis Patients and Effect of Hemodialysis on These Cardiac MarkersCardiology, 1998
- Greater frequency of increased cardiac troponin T than increased cardiac troponin I in patients with chronic renal failureClinical Chemistry, 1996
- Discordance between results for serum troponin T and troponin I in renal diseaseClinical Chemistry, 1995
- Morbidity and Mortality of Renal Dialysis: An NIH Consensus Conference StatementAnnals of Internal Medicine, 1994
- Cardiovascular aspects in renal diseaseCurrent Opinion in Nephrology and Hypertension, 1993
- Cardiac troponin I. A marker with high specificity for cardiac injury.Circulation, 1993