Prognostic significance of epidermal growth factor receptor in esophageal squamous cell carcinomas
Open Access
- 1 June 1989
- Vol. 63 (11), 2169-2173
- https://doi.org/10.1002/1097-0142(19890601)63:11<2169::aid-cncr2820631117>3.0.co;2-w
Abstract
The prognostic value of epidermal growth factor (EGF) receptor level was studied in 32 patients with esophageal squamous cell carcinoma. The EGF receptor levels of tumors were measured by iodine 125 (125I)‐EGF binding assay, and the patients subsequently were divided into two groups: a group with high EGF binding capacities (< 2.5% of input), and a group with low EGF binding capacities (P < 0.05). In tumors from two patients with the highest EGF receptor levels, EGF receptor gene amplification was observed. These patients developed mediastinal lymph node metastasis and died 4 and 11 months after surgery, respectively. These results suggest that elevated EGF receptor level is a significant prognostic indicator for esophageal squamous cell carcinoma.This publication has 20 references indexed in Scilit:
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