The effect of Pyridoxine on Oxalate Dynamics in three Cases of Primary Hyperoxaluria (with Glycollic Aciduria)
- 1 July 1985
- journal article
- research article
- Published by Portland Press Ltd. in Clinical Science
- Vol. 69 (1), 87-90
- https://doi.org/10.1042/cs0690087
Abstract
Glomerular filtration rate (GFR), extracellular fluid volume (ECF), oxalate distribution volume (OxDV), plasma oxalate concentration (POx), plasma total clearance of oxalate (PCOx), oxalate metabolic pool size [(OxDV) .times. (POx)], renal clearance of oxalate (RCOx), oxalate excretion, tissue clearance of oxalate (TCOx,) and tissue oxalate accumulation rate [(TOx.A) = (TCOx.) .times. (POx.)] were measured in 3 patients with type I primary hyperoxaluria (hyperoxaluria with hyperglycollic aciduria) when they were taking pyridoxine and after discontinuation of the vitamin. Seven days after stopping pyridoxine the plasma oxalate concentration, oxalate metabolic pool size and the urinary excretion of oxalate had all increased between 7- and 8-fold in 2 of the patients. The 3rd patient showed no changes on stopping pyridoxine. These results support the view that pyridoxine acts by reducing oxalate biosynthesis in some patients with type I primary hyperoxaluria. The possible biochemical basis for this effect is discussed.This publication has 7 references indexed in Scilit:
- Oxalate Dynamics and Removal Rates during Haemodialysis and Peritoneal Dialysis in Patients with Primary Hyperoxaluria and Severe Renal FailureClinical Science, 1984
- Sequential Studies of Oxalate Dynamics in Primary HyperoxaluriaClinical Science, 1983
- STUDIES ON SOME POSSIBLE BIOCHEMICAL TREATMENTS OF PRIMARY HYPEROXALURIA1979
- Metabolism of [1−14C]glyoxylate, [1−14C]-glycollate, [1−14C]glycine and [2−14C]-glycine by homogenates of kidney and liver tissue from hyperoxaluric and control subjectsBiochemical Journal, 1967
- Deficiency of 2-oxo-glutarate: glyoxylate carboligase activity in primary hyperoxaluria.Proceedings of the National Academy of Sciences, 1967
- The metabolism of glyoxylate by human- and rat-liver mitochondriaBiochemical Journal, 1962
- Oxalosis and primary hyperoxaluriaThe Journal of Pathology and Bacteriology, 1959