Cognitive function in hypertensives treated with atenolol or propranolol
- 1 July 1990
- journal article
- conference paper
- Published by Springer Nature in Journal of General Internal Medicine
- Vol. 5 (4), 310-318
- https://doi.org/10.1007/bf02600398
Abstract
Study objective:To test reports that beta blockers, particularly lipopbilic forms, impair cognitive function and cause psychiatric disturbances. Design:Randomized, double-blind, controlled crossover trial with eight-week treatment periods. Patients:Sequential sample of 43 male veterans, with untreated diastolic blood pressures (DBP) between 90 and 110 mmHg, aged 35–64 years. Interventions:Propranolol-LA, 80-mg tablets, or atenolol, 50-mg tablets, were given daily, incremented by one tablet at weekly intervals until DBP ≤90 mmHg. Hydrochlorothiazide was added, if necessary. Main results:Repeated-measures ANOVA was performed on all cognitive tests. Cognitive test performance was not affected by beta blocker therapy in seven of nine tests and was enhanced on Trail Making Test. Performance was impaired only on Digit Cancellation. Neither Speilberger’s State Trait Anxiety Inventory nor the Beck Depression Inventory was affected by either beta blocker. Conclusions:Atenolol or propranolol therapy does not impair cognitive function or contribute significantly to psychiatric side effects.Keywords
This publication has 38 references indexed in Scilit:
- Clinical significance of cognitive performance by hypertensive patients.Hypertension, 1987
- Neuropsychological deficits in arterial hypertensionActa Neurologica Scandinavica, 1986
- CNS-related side-effects with metoprolol and atenololEuropean Journal of Clinical Pharmacology, 1985
- Relationship of free-recall memory to hypertension in the elderly. The Iowa 65+ Rural Health StudyJournal of Chronic Diseases, 1985
- Effect of antihypertensive treatment on the behavioral consequences of elevated blood pressure.Hypertension, 1984
- Behavioral consequences of mild hypertension.Hypertension, 1982
- Cognitive processes in hypertension.Hypertension, 1982
- Psychiatric Aspects of HypertensionThe British Journal of Psychiatry, 1975
- ELECTROCARDIOGRAM, PLASMA CATECHOLAMINES AND LIPIDS, AND THEIR MODIFICATION BY OXPRENOLOL WHEN SPEAKING BEFORE AN AUDIENCEThe Lancet, 1973
- Intelligence and Blood Pressure in the AgedScience, 1971