Some Metabolic Effects of Sodium Nitroprusside in Man
- 20 April 1974
- Vol. 2 (5911), 140-142
- https://doi.org/10.1136/bmj.2.5911.140
Abstract
The infusion of sodium nitroprusside during surgical operations produced plasma levels of cyanide of up to four times the control value. Plasma thiocyanate showed little change except during prolonged infusion of the drug, but total plasma B12 tended to fall, as did methylcobalamin. Other cobalamins showed little change after nitroprusside infusion for short periods. During longer infusions the ratio of methylcobalamin to adenosyl + hydroxocobalamin fell and cyanocobalamin concentrations were high.Keywords
This publication has 18 references indexed in Scilit:
- Nitroprusside revisited.BMJ, 1971
- SODIUM NTTROPRUSSIDE IN THE SURGICAL TREATMENT OF CEREBRAL ANEURYSMS AND ARTERIOVENOUS MALFORMATIONSBritish Journal of Anaesthesia, 1971
- Chromatographic and Bioautographic Estimation of Plasma Cobalamins in Various Disturbances of Vitamin B12 MetabolismClinical Science, 1971
- SODIUM NITROPRUSSIDE AS A HYPOTENSIVE AGENT IN GENERAL ANAESTHESIABritish Journal of Anaesthesia, 1970
- FREE-CYANIDE LEVELS IN TROPICAL ATAXIC NEUROPATHYThe Lancet, 1970
- Patterns of plasma cobalamins in control subjects and in cases of vitamin B12deficiencyJournal of Clinical Pathology, 1969
- Sodium nitroprusside as a hypotensive agent.1968
- ANTAGONISM OF EXPERIMENTAL CYANIDE TOXICITY IN RELATION TO IN VIVO ACTIVITY OF CYTOCHROME OXIDASE1968
- Results with radioisotopic assay of serum B12using serum binding agentJournal of Clinical Pathology, 1967
- Metabolic inter-relationships between cyanide, thiocyanate and vitamin B 12 in smokers and non-smokers.1966