Vinblastine plus Bleomycin Continuous Infusion Chemotherapy of Stage III Testicular Carcinomas

Abstract

Thirty-four consecutive patients with stage III testicular carcinomas were treated with vinblastine, 8 mg/m² given in 2 fractions on day 1 and 2, followed by continuous intravenous administration of bleomycin, 15 mg/m² in 1000 cc of 5 % glucose and distilled water over a 24-hour period for 5 successive days beginning on day 2. This cycle was repeated every 28-35 days as toxicity permitted. Complete remission occurred in 18 % and complete plus partial remission in 79 %. Only 2 of 22 patients with advanced abdominal disease achieved a complete remission. After cytoreductive surgery the complete remission rate was increased to 39 %. Median survival of complete responders at 3 years has not been reached, and it has been shown to be significantly superior to that of partial (p < 0.01) and nonresponders (p < 0.01). Toxic effects consisted mainly in severe leukopenia, stomatitis, adynamic ileum and osteoarticular pain. One drug-related death due to sepsis with agranulocytopenic fever was observed. Probably because of different patient selection, this report could not reproduce the results reported by Samuels et al. with equivalent drug dosage, but it was confirmed that this regimen is able to achieve a high overall response rate and a prolonged median survival in complete responders. The consistent success of this aggressive combination in inducing a high percentage of partial responses has opened the way for a better definition of the role of surgery for the treatment of advanced testicular carcinoma at our Institute.