Ligand‐Clustered “Patchy” Nanoparticles for Modulated Cellular Uptake and In Vivo Tumor Targeting
Open Access
- 25 August 2010
- journal article
- research article
- Published by Wiley in Angewandte Chemie International Edition
- Vol. 49 (40), 7266-7270
- https://doi.org/10.1002/anie.201003445
Abstract
A matter of presentation: The manner in which polyvalent ligands are presented to a cell—homogeneously or in spatially defined groupings on a nanoparticle surface—may play an important role in cellular uptake. This aspect is investigated for the first time using a linear dendritic polymer construct to pattern the surfaces of nanoparticles with variable‐sized ligand clusters in different spatial arrangements.Keywords
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