Pulmonary mechanics in normal rats

Abstract

A versatile, whole-body, pressure, or volume plethysmographic system for the study of pulmonary mechanics in anesthetized, tracheotomized rats was described. Lung volumes and lung compliance values were in good agreement with those previously reported. Pulmonary resistance and chest wall compliance values were lower than those previously reported. Total dynamic compliance remained independent of respiratory frequency between 40 and 320 breaths/min. Flow-limiting behavior was demonstrated from a series of imposed forced expiratory maneuvers of graded effort. With a deflation pressure of 30 cm H2O, the effort-independent range of maximum flow extended to 40-50% of vital capacity. Maximal flow-static recoil pressure relationships were essentially linear over the effort independent portion of the flow-volume curve. Substitution of a low-density gas mixture (80% He-20% O2) for air reulted in increased forced expiratory flow rates but the magnitude of the response was considerably less than that which was reported in man.