The Wolf‐Hirschhorn syndrome
- 1 June 1980
- journal article
- research article
- Published by Wiley in Clinical Genetics
- Vol. 17 (6), 375-384
- https://doi.org/10.1111/j.1399-0004.1980.tb00167.x
Abstract
Four new cases of the Wolf-Hirschhorn syndrome are presented, 2 of which were due to t(4;22)mat. Review of the literature (> 100 cases of the Wolf-Hirschhorn syndrome) showed that 13% of all the reported cases were not mutations but segregations of parental chromosomal aberrations, primarily translocations. Similar data were obtained previously for other deletions (5p-, 18p-, 18q-). Analysis of data on some new deletion syndromes (Hq-, 8p-, 9p-, 10p-, 11p-, 11q-) revealed that 14.5% were inherited cases. All human autosomal deletions apparently have virtually the same genetic pattern.Keywords
This publication has 34 references indexed in Scilit:
- A cytogenetic survey of an institution for the mentally retarded: I. Chromosome abnormalitiesClinical Genetics, 2008
- The Wolf‐Hirschhorn syndromeClinical Genetics, 1980
- Cytogenetic studies in patients with cleft lip and/or cleft palate (IV)Journal of Human Genetics, 1978
- The 9p- deletion syndrome A patient with a 45,XX,-9,-15, + t(9/15) constitution due to maternal 3:l meiotic disjunctionClinical Genetics, 1977
- Proximal 4p-deletion: Phenotype differs from classical 4p-syndromeThe Journal of Pediatrics, 1977
- The 9p‐ deletion syndrome. Report of a patient with a 46, XX, 9p‐ constitution due to a paternal t(9p‐; 15q+) translocationClinical Genetics, 1975
- Partial monosomies 18Human Genetics, 1972
- A complex chromosomal rearrangement with formation of a ring 4.Journal of Medical Genetics, 1971
- Wolf-Hirschhorn syndrome associated with an unusual abnormality of chromosome no. 4.Journal of Medical Genetics, 1970
- Chromosome abnormalities in two cases with bilateral radial element defects.Journal of Medical Genetics, 1969