Photochemical attachment of cyclic AMP binding protein(s) to the nuclear genome
- 1 February 1977
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 265 (5596), 705-710
- https://doi.org/10.1038/265705a0
Abstract
The nature of the cyclic[c]AMP-receptor-nucleus interactions was examined by a novel combination of 2 photoreactions. A photosensitive derivative of cAMP, N6-butyryl cAMP, was covalently attached to its cytoplasmic receptod by photo-affinity labeling and this receptor complex was photo-crosslinked by the DNA in the rat liver nuclei. The photolytic reactions seemed to be specific since stable links were formed only when substantial noncovalent binding occurred.This publication has 23 references indexed in Scilit:
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