Chlormerodrin Hg 203 and Electrolyte Distribution in Murine Brain Tumors

Abstract

THE EMERGENCE of scintillation scanning of the brain for localization of brain tumors has been a major advance in neurological diagnosis. Moore,¹ in 1948, was able to localize brain tumors by the use of radioactive iodine-labeled diiodofluorescein and a Geiger-Meuller tube. Since this time there have been major technological advances with the development of sensitive scintillation counters, automatic scanning equipment, and focusing collimators.² The most commonly employed agent for brain tumor localization has been iodinated I 131 serum albumin,³ although other compounds have been employed. In 1959, Chlormerodrin Hg-203 was introduced as an agent for brain tumor localization by Blau and Bender,⁴ and numerous reports since have attested to its value in brain tumor localization.^5-8 The mechanism of localization of brain tumors by scintillation scanning has received some attention in the literature but further information is needed to understand more fully the manner in