THE INFLUENCE OF DIETARY PROTEIN INSUFFICIENCY ON THE MURINE THYMUS. EVIDENCE FOR AN INTRATHYMIC POOL OF PROGENITOR CELLS CAPABLE OF THYMUS REGENERATION AFTER SEVERE ATROPHY
- 1 October 1977
- journal article
- research article
- Published by Wiley in Immunology & Cell Biology
- Vol. 55 (5), 571-584
- https://doi.org/10.1038/icb.1977.56
Abstract
Low protein diets initiated at weaning in Balb/c mice cause a rapid and profound reduction in thymus weight and cellularity. Thymus weight falls to less than that of the involuted thymus of adult mice and remains depressed for as long as diets are fed. Although most peripheral T cell functions do not appear to be depressed, suppressor cell activity was not as vigorous in deprived animals despite the presence of functional suppressor populations. Thymus growth was reinitiated promptly when high protein diets were fed to deprived animals. Thymus regeneration appeared to he due to both a resident population of stem cells which persisted in the thymus through the period of deprivation and a second, probably bone-marrow derived, population of stem cells. It is suggested that in normal mice the synchronized growth of the first population produces the characteristic innate growth pattern of the thymus. This is superimposed on the growth of the second population which continuously seeds the thymus and is constantly replaced. Protein deprivation severely restricts the growth of the first and second population, but both maintain their capacity for growth during long periods of protein restriction.Keywords
This publication has 7 references indexed in Scilit:
- Hematopoietic thymocyte precursors. I. Assay and kinetics of the appearance of progeny.The Journal of Experimental Medicine, 1976
- Influence of diet on survival of mice.Proceedings of the National Academy of Sciences, 1976
- EFFECTS OF NUTRITIONAL REHABILITATION ON ANTIBODY-PRODUCTION IN PROTEIN-DEFICIENT MICE1976
- INFLUENCE OF DIETARY-PROTEIN RESTRICTION ON IMMUNE COMPETENCE .2. EFFECT ON LYMPHOID-TISSUE1976
- Antitrinitrophenyl (TNP) Plaque Assay. Primary Response of Balb/c Mice to Soluble and Particulate ImmunogenExperimental Biology and Medicine, 1969
- A Method of Increased Sensitivity for detecting Single Antibody-forming CellsNature, 1965
- THE AUTONOMOUS BEHAVIOUR OF NORMAL THYMUS GRAFTSImmunology & Cell Biology, 1963