Influence of Adrenergic Blocking Drug [N-Ethyl-N-(2-bromoethyl)-l-naphthylenemethylamine {middle dot} HBr] On Pyrogenic Reaction.

Abstract

Summary A potent adrenergic blocking drug, N-Ethyl-N- (2-bromoethy1)-1-naphthyl-enemethylamine · HBr, has been shown to reduce and alter the febrile response of normal and curarized dogs to the intravenous injection of a purified pyrogenic material obtained from pseudomonas aeruginosa. This evidence is interpreted as supporting the hypothesis that the pyrogenic reaction is due, at least in part, to a reduction in heat loss caused by adrenergic nerve mediated vasoconstriction in the skin.